Cartoning Machine

A GMP-compliant cartoning system offering ±0.5mm positioning accuracy, 99.99% pass rate, strong adhesion, and full traceability—ideal for high-precision packaging of diverse liquid formulations.

This advanced cartoning system is designed to meet the stringent demands of pharmaceutical and biotech industries by ensuring high precision, strong adhesion, and full traceability for packaging various types of liquid formulations. It achieves a positioning accuracy of ±0.5mm with bottle/bag insertion deviation ≤±1mm, eliminating issues like jamming, missing, or incorrect loading, thus achieving a 99.99% pass rate.

The system ensures excellent paper box forming precision with neatly folded edges (deviation ≤±0.3mm) and robust bonding, providing a peel strength ≥5N/25mm, which guarantees no glue failure or deformation, meeting transportation packaging standards. The accuracy rate for inserting instructions is 100%, supporting automatic folding and precise placement of single-page/multi-page instructions without omission, inversion, or creasing, suitable for different instruction sizes.

The system’s design includes flexible conveying and cushioned positioning, preventing product damage (breakage rate ≤0.005%) and ensuring the integrity of liquid formulation packaging. Various sealing methods such as hot melt adhesive, pressure-sensitive adhesive, and tuck-in flaps are supported, ensuring flat seals without excess glue, making it resistant to drops and vibrations, ideal for long-distance transportation.

Supporting mixed packaging of multiple specifications (e.g., 1 bottle + 1 instruction + 1 gift), the system maintains a material ratio accuracy of 100%, avoiding underloading or overloading. Excellent repeatability within batches ensures consistent product appearance. Precise detection of unopened or partially opened boxes allows for automatic rejection, enhancing subsequent cartoning efficiency.

Fully compliant with GMP, FDA 21 CFR Part 11, EU GMP Annex 11, the system includes tamper-proof electronic batch records (EBR) storing parameters like speed, pass rate, box batches, and operator data. IQ/OQ/PQ validation packages and material compatibility reports facilitate rapid GMP certification. Full traceability through barcode/QR code linking bottle/bag batches, box batches, instruction batches, and cartoning parameters ensures tracking from production to end-user.

Designed for flexibility, the system supports various types of liquid formulation containers and box sizes, including rectangular, square, and custom-shaped boxes, accommodating 1-50 bottles/bags per box. With a capacity range of 30-300 boxes/min, it supports small-scale trials, pilot runs, and large-scale production, enabling quick changeovers (≤20 minutes). Modular design allows seamless integration with labeling machines, palletizers, and inspection equipment, facilitating an “all-in-one” automated process from labeling to cartoning and palletizing.

Operated via PLC + touchscreen controls, it offers 100+ programmable cartoning recipes, real-time monitoring, and self-diagnosis features, facilitating remote management and rapid fault resolution. Energy-saving technologies ensure low maintenance costs and long service life with international components, while also reducing waste and improving efficiency.

CategorySpecification / Feature
Cartoning Positioning Accuracy±0.5 mm; bottle/bag insertion deviation ≤±1 mm
Box Forming PrecisionNeatly folded edges (deviation ≤±0.3 mm); peel strength ≥5N/25mm
Instruction Insertion Accuracy100%; supports single/multi-page folding and insertion
Product Damage Rate≤0.005%; flexible conveying and cushioned positioning
Sealing MethodsHot melt adhesive, pressure-sensitive adhesive, tuck-in flaps
Mixed Packaging SupportSupports 1 bottle + 1 instruction + 1 gift; material ratio accuracy 100%
Batch ConsistencyParameter deviation ≤±0.5%
Regulatory ComplianceGMP, FDA 21 CFR Part 11, EU GMP Annex 11
Data IntegrityTamper-proof EBR; logs speed, pass rate, box batches, operator data
Validation DocumentationFull IQ/OQ/PQ, cartoning process validation report, material compatibility report
Material Compatibility316L SS, food-grade plastics; meets USP Class VI
Cleanroom ClassificationSupports CIP online cleaning
TraceabilityBarcode/QR links bottle/bag batches, box batches, instruction batches, cartoning params
CertificationsCE, ISO 9001, FDA registered
Capacity Range30–300 boxes/min
Integrated ModulesAutomatic feeding, product sorting, instruction insertion, anti-counterfeiting label application, coding
Changeover Time≤20 minutes
Special FunctionsFlexible sealing options
Modular DesignScalable modules for seamless integration
Automation LevelFully automatic feeding → forming → loading → insertion → sealing → inspection
Control SystemPLC + color touchscreen; manual/auto modes
Remote OperationReal-time monitoring via PC/mobile; multi-language support
Fault DiagnosisAuto-detect missing boxes, products, instructions, insufficient glue
Safety FeaturesOverload protection, anti-pinch protection, emergency stop, door interlock
MaintenanceLow-maintenance international components; detailed manuals & video tutorials

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